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External validation of the original model showed excellent discriminative performance in predicting functional independence (C statistic 0.91[0.90, 0.92]) and survival (C statistic 0.89[0.84, 0.94])

Additionally, in muscle tissue, mitochondrial translation and respiratory genes were also induced, and moreover, patients demonstrated a mild clinical improvement

Likewise, the inhibition of catabolic pathways (IL-6, TNF-alpha), balanced with the stimulation of anabolic pathways (FoxO3a, p-AKT, p-mTOR, and P-GSK-3), has occurred in the counteraction of tumor-induced cachexia [56]