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Immunodeficiency, centromere instability, and facial abnormality syndrome ICF syndrome is a rare autosomal recessive genetic disorder characterized by fatigue, facial abnormalities, and cognitive deficits (78)

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Reduces oxidative stress with powerful antioxidant properties

Hydrogen sulfide protects against cellular senescence via s-sulfhydration of Keap1 and activation of Nrf2

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It has been suggested that ALA predominantly ameliorates oxidative stress in the mammalian brain through NRF2 activation (Macias-Barragan et al., 3) and microarray data (Table S4) of mouse brains did not reveal any changes in NFE2L2 mRNA levels and signaling pathway, indicating that the observed ALA effects on gene expression are mediated by another signaling pathway
