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The propensity of SOD1 to unfold and aggregate has been shown to correlate with life expectancy after ALS symptom onset in humans and transgenic mouse models 8,14,15,16

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Mobley DL, Wymer KL, Lim NM, Guthrie JP (2014) Blind prediction of solvation free energies from the SAMPL4 challenge

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Unfortunately, patients often meet the KCC and lactate criteria quite late in the course of the disease, so these criteria are not useful as early predictors or as standards for transfer to a facility that performs the hepatic transplant

This peptide therapy may be incorporated into personalized wellness programs under provider supervision