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Many studies have reported that the downregulation of PGC-1 was associated with abnormal mitochondrial biogenesis and diminished ATP production capacity, and the reduced mitochondrial biogenesis in hepatocytes by silica nanoparticles was also associated with the inhibition of the PGC-1/NRF-1/TFAM pathway (81)

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doi:10.1097/DBP.0000000000000285 Stein MA, Zulauf-McCurdy C, DelRosso LM