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These epigenetic shifts can deregulate tumor-related genes, setting the stage for malignant transformation [79]

ICH Q1A (R2) Stability Testing Guidelines: Stability Testing of New Drug Substances and Products (CPMP/ICH/2736/99)

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23 Studies using GLT1 deficient mice, which express only 20% of normal GLT1 levels to simulate chronic GLT1 reduction, have shown that these mice exhibited a phenotype resembling attentiondeficit/hyperactivity disorder, including hyperactivity, impulsivity, and impaired memory

Arginine is the direct precursor for the synthesis of creatine, an energy storage molecule as creatine phosphate, and the critical gasotransmitter, nitric oxide, NO

Social isolation impairs the persistence of social recognition memory by disturbing the glutamatergic tonus and the olfactory bulb-dorsal hippocampus coupling