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NNMT activity is known to increase as aging progresses or in response to certain lifestyle factors, often resulting in a decline in metabolic efficiency and a buildup of stubborn fat

For the duration of the study, animals were singly housed in standard individually ventilated cages (Innovive, San Diego, CA) with nesting material enrichment (ALPHA-Twist

Compliance note

Abstract Osteoarthritis is a common degenerative joint disease characterized by progressive cartilage loss, bone remodeling, and chronic joint inflammation, yet its underlying mechanisms remain incompletely understood

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