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doi: 10.1002/mnfr.200400098 158 MacCarroneMLorenzonTGuerrieriPAgrAF

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TABLE 2 Compound ( 10 ' 12 M) HGF Mimetic Activity N- heptanoyl-Tyr-Ile-(6) aminohexamide N- hexanoyl-Tyr-Ile-(6) aminohexamide ++++ N- pentaanoyl-Tyr-Ile-(6) aminohexamide _j N- butanoyl-Tyr-Ile-(6) aminohexamide +++ N- propananoyl-Tyr-Ile-(6) aminohexamide ++ N- acetanoyl-Tyr-Ile-(6) aminohexamide + N- benzoyl-Tyr-Ue-(6) aminohexamide + N- hexanoyl- (CH 2 -NIT 2 )-Tyr-Ile-(6) aminohexamide +++ Cell culture

In comparison, the standard drug zileuton had an IC 50 value of 1.04 M

Worse still, their accumulation in tissues contributes to chronic inflammation, degenerative diseases and general ageing of the body