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About 50% of the histamine in the brain is from mast cells.[ref] Diphenhydramine (Benadryl) has the side effect of making people sleepy due to blocking the actions of histamine in the brain
One study shows that women who had lower than 250 mg/Dl levels of vitamin B12 were 3x more likely to give birth to a child with a birth defect than those who didnt
doi: 10.1136/gutjnl-2012-304058
Absolute contraindications include active malignancy, pregnancy, and lactation
Critical Reviews in Clinical Laboratory Sciences
