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The practicality of using ESM1 in clinical settings is bolstered by its status as a secreted protein readily detectable in blood samples

A single fresh receptor can produce near-maximum output at about 10% engagement, while a normal meal uses only 1% to 4% (receptor saturation)

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a study utilizing doubly labeled 5-methyltetrahydrofolate and 5-formyltetrahydrofolate

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