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Under Erastin treatment, the proportion of SA--gal positive cells, a classic marker of senescence, significantly decreased with the addition of the ferroptosis inhibitor Fer-1 [134]

Stability of iron complexes in the presence of GSSG The negative ionization mode mass spectrum for complex 1 after 1 min of incubation with GSSG showed two signals at m/z = 229 and at m/z = 611, corresponding to ferrocenecarboxylic acid and the GSSG molecule

10.1038/nbt.1502 67 HumphriesB.YangC

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Indeed, superoxide can undergo dismutation to H 2 O 2 , a mild oxidant that can be converted to the highly reactive hydroxyl radical in the presence of transition metals (Fe 2 + , Cu + ) by means of the Fenton reaction

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