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Mdm2 and Mdmx Promote Ferroptosis by Pparalpha-Mediated Lipid Remodeling

1,25(OH)D facilitates the transcriptional activation of MKP5 by promoting the binding of the VDR/RXR heterodimer to the VDRE within the MKP5 promoter region [205].Building on this, 1,25(OH)D not only regulates downstream MAPK cascades via MKP5 upregulation but also interacts with transcription factors such as NF-B, NFAT, and the glucocorticoid receptor (GCR) through its VDR/RXR complex, orchestrating a multi-level anti-inflammatory response

10.2174/0115680266337430241127112031 134 WellingtonV

Therefore, computational studies were performed to determine the effect of doping on the structural properties

Xiong et al., 2016
