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If this occurs across multiple subjects, the treatment may incorrectly appear ineffective

In vitamin B-12 deficiency, folic acid can produce complete resolution of the characteristic megaloblastic anemia, while allowing potentially irreversible neurological damage (from continued inactivity of methylmalonyl mutase) to progress

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However, those coverage increases have not yet been fully realized

While the clinical trial was extensive enough to gain FDA approval for the treatment, the longest that some patients were observed for risks and side effects was six monthsand that was only a portion of the participants from the clinical study

Pregnant or breastfeeding women should avoid AOD-9604 due to lack of safety data in these populations