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Thymoquinone (TQ) has been shown to significantly reduce levels of proinflammatory cytokines, such as IL-6, which is implicated in various psychological confditions, including depression and anxiety

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2019;9(3):e23353

Clinical and animal studies have demonstrated that a major physiological consequence of total parenteral nutrition is the loss of intestinal barrier integrity.52 Mice administrated with total parenteral nutrition show increased intestinal paracellular permeability and decreased levels of TJ proteins, which is reversed by IL-10 treatment.53 Collectively, IL-10 restores the intestinal barrier defect