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Third, we found that GSH depletion induced SIPS

in particular, several reports dealt with the identification of inhibitors for ASCT2 (91) and LAT1 (92) via bioinformatics

Vitamin D has been shown to reduce serum levels of inflammatory cytokines, including IL-3 (151), IL-17 (151, 152), IL-1, IL-6, IL-8, and TNF- (153), and may directly act on CD4 + T cells to promote the secretion of the anti-inflammatory cytokine IL-10 by T regulatory cells (Tregs), controlling the further expansion of the inflammatory response (151, 152, 154, 155)

These observations support Braaks hypothesis, which postulates that -synuclein pathology, underlying PD, may originate in the GI tract

Beyond salivary gland involvement, systemic dissemination frequently affects other organs, particularly in postpubertal males

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