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Immunostaining of lung tissue from the same regions on which we performed gene expression analysis localized SMAD2, a down-stream signal transducer of TGF, to the alveolar and airway walls while members of the bone morphogenetic protein (BMP) pathway, including SMAD6 and SMAD1, were primarily seen in vascular endothelial cells (Additional file 9)

However, standard methods of IGF-I measurement are not well characterized yet

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Patients with Diabetes mellitus have elevated CRP levels in their blood, which can be used as a diagnostic marker in non-healing diabetic wounds ( Table 1 )