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Elevated circulating TMAO concentrations have been not only linked to an increased risk of cardiovascular disease but also to an increased risk for type 2 diabetes mellitus and kidney disease (117-119)

Although the renal clearance rate of this metabolite is typically high, renal insufficiency in chronic kidney disease (CKD) reduces TMAO clearance in CKD patients, elevating plasma levels of both TMAO and choline 10 and exacerbating poor renal function 8

Heterogeneous Expression of Gamma-Aminobutyric Acid and Gamma-Aminobutyric Acid-Associated Receptors and Transporters in the Rat Suprachiasmatic Nucleus. The Journal of Comparative Neurology, vol

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