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Moreover, TNF- stimulation triggers MEKK2-dependent STK38 activation, which in turn phosphorylates RIPK1 at serine 309, a residue conserved only in higher primates

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Keap1 is a suppressor protein of Nrf2, which is a major regulator of oxidative responses

In host amphibian cells, Bd infection decreased intracellular glutathione content and increased reactive oxygen species, suggesting that chytridiomycosis pathogenesis may involve oxidative stress

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Together, these actives deliver antioxidant protection, promote skin renewal, and help maintain a healthy skin-gut connection