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In the SOD1 G93A mouse model of ALS, pyruvate (1000 mg/kg/week i.p.) slowed disease progression and also improved motor symptoms in a rotarod test and survival by 10.5% when it was administered starting at the onset of disease (Park et al., 2007)

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Patients with diabetes and CAD were similarly analyzed

17 GT1a patients with a prior null response had a cure rate of 80% for 12 weeks compared with 92.9% for 24 weeks