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27 Subsequent structural optimization of 4 led to the identification of JBSNF-000265 ( 5 ) with an IC 50 value of 0.58 0.07 M, displaying a 3-fold improvement in activity with a favorable pharmacokinetic profile

The most serious potential side effect of rituximab is progressive multifocal leukoencephalopathy (PML), an infection of the brain, which can manifest in a number of ways including trouble with gait, speech and memory

Proper patient screening and sterile technique help maintain treatment safety

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This means AOD 9604 can be used for extended periods without diminishing returns from antibody-mediated inactivation