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PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma

The mechanisms studied in animal models include growing new blood vessels (angiogenesis, via VEGFR2), helping repair cells move to the injury (fibroblast migration, via the FAK-paxillin pathway), and supporting blood flow through the nitric-oxide pathway

Specificity: Designed to probe multiple metabolic targets simultaneously: NNMT inhibition (5-Amino-1MQ), AMPK activation and nuclear gene regulation (MOTS-c), and sirtuin/PARP substrate replenishment (NAD+)

Science's STKE 2007 (413), pe64

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How Does Glutathione Work for Skin Whitening