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enhance skeletal muscle proteolysis

This cytokine signaling is a key component of the sickness response (98), which has symptoms that overlap with key ME/CFS symptoms (105, 106)]

Without co-stimulatory signals on the antigen-presenting cell (in this case the cancer cell), CD4+ T cells will not differentiate into effector cells in response to antigens, which prevents an effective immune response

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PMID: 25019433

Numerous investigations have suggested that disruption of the GSH system is a critical element in the pathogenesis of myocardial injury