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It influenced mtROS production and lipid peroxidation, thereby activating necroptosis and ferroptosis
The model expresses full-length human ATXN3 with 84 glutamine repeats throughout the brain, capable of reproducing clinical features of SCA3 including locomotor deficits, cerebellar neuronal loss and progressive cerebellar degeneration

Targeting the PI3K pathway in cancer: are we making headway

Brady HM

M., Mills, A
