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GPX3 has been identified as a genetic risk locus shared among Alzheimers disease and related dementias, PD, and ALS [180]
The oxidation steps, utilizing glucose-6-phosphate (G6P) as the substrate, occur at the beginning of the pathway and are the reactions that generate NADPH
While the TRIUMPH-4 results are in, additional trials including TRIUMPH-1, TRIUMPH-2, and TRIUMPH-3 are ongoing or planned
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