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Ghiadoni L, Magagna A, Versari D, Kardasz I, Huang Y, Taddei S, Salvetti A

One of these is called necroptosis that represents a programmed form of necrosis 28,44

2.6 Immunogenic cell death Prior to the identification of ICD, apoptosis was typically regarded as a non-immunogenic process

Nitric oxide and energy production in articular chondrocytes

Lon protease binds PYCR1, a key enzyme in proline metabolism, enhancing NADPH consumption and promoting electron leakage in the ETC, thereby elevating mtROS (45)

Whatever the case, we infer that inhibiting TCA activity actually protects ER homeostasis in part because of its effects on ER ultrastructure