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Simultaneously, targeting hepatic sirtuin 1 and cytochrome P450 2E1(CYP2E1) may also provide therapeutic benefits in ALD, principally through lipid peroxidation reduction [20, 785, 786]

doi: 10.1080/01913123.2018.1551259 34 SuSRugisJWahlADoakSLiYSureshVet al

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I., Liu, J

[1] Symptoms of B12 deficiency develop gradually and may include: Persistent fatigue and weakness Neurological symptoms such as paraesthesia (pins and needles), particularly in hands and feet Cognitive changes including memory problems or confusion Glossitis (sore, red tongue) and mouth ulcers Mood disturbances including depression or irritability Balance problems and difficulty walking Neurological complications can become irreversible if left untreated , making prompt diagnosis and treatment essential