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Tirzepatide activates both GIP and GLP-1 receptors, while semaglutide activates GLP-1 receptors
Unlike direct GPX4 inhibition, which remains difficult to deploy in vivo owing to bioavailability and systemic toxicity concerns, targeting enzymes that sustain the reduced CoQ 10 (CoQ 10 H 2 , ubiquinol) pool may provide a more tractable and context-selective strategy to lower the ferroptotic threshold in tumors

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[DOI] [PubMed] [Google Scholar] [105].Horwitz DA, Bickerton S, La Cava A

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