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POSITRON reported an SVR12 of 68% (n = 57/84) after 12 weeks of SOF/RBV for HCV-3 subjects without cirrhosis and 21% (n = 3/14) SVR12 for those with cirrhosis, confirming overall low rate of SVR12 in HCV-3 with 12 weeks of therapy, and an unacceptable relapse rate in patients with cirrhosis in particular

Again, in exceedingly rare circumstances, lidocaine toxicity can occur, causing serious heart and central nervous system problems

Purification of a cystic fibrosis plasmid vector for gene therapy using hydrophobic interaction chromatography
3D, see Supplementary Methods for details) 55

2017;4:e103
And it plays a role in buffering the mitochondrial acyl-CoA pool, helping maintain metabolic flexibility, the ability to switch between fat and carbohydrate as fuel sources depending on demand
