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Injection: Picking Your Route Subcutaneous injection: More established route 45 to 60 minute onset 4 to 6 hour duration More precise dose delivery Requires self-injection (subcutaneous, small needle, simple technique) Intranasal: Faster onset (20 to 45 minutes) 3 to 5 hour duration (slightly shorter) No needles Dose precision is reasonable but less exact than injection Some patients find the nasal experience uncomfortable or report a bitter taste Where this falls apart is overthinking it