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Apart from providing protection, nanocarriers and nanoplatforms that have been engineered to appropriate size and surface properties have demonstrated an enhancement in buccal peptide delivery using in vitro or ex vivo models

To address the critical issue of BBB permeability, studies using [H]Dihexa and [C]inulin in rats revealed that Dihexa avidly concentrated in all examined brain regions including the prefrontal cortex, hippocampus, hypothalamus, striatum, thalamus, midbrain, brain stem, and cerebellum, compared to blood

In both BDL and lithocholic acid-treated Huh-7 cells, the fall in expression of GSH synthetic enzymes coincided with an increase in the expression of several Maf proteins (c-Maf, MafG and MafK) as well as increased c-Maf and MafG nuclear binding to ARE

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Most protocols recommend avoiding food for 2 to 3 hours before injection and waiting at least 30 minutes after injection before eating