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Its effects tend to diminish after 46 weeks of daily use, so strategic breaks are essential to reset the bodys responsiveness and restore its full effectiveness

The honest answer is that it depends on the indication, and the timeline varies enough between tissue types that a single number is misleading

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Features that distinguish acneiform eruptions from acne vulgaris are: a positive time relationship between the introduction of the drug and the onset, a sudden and uncommon age of onset, pruritus, a monomorphic pattern and an involvement of seborrheic and extra-seborrheic areas such as the face, the neck, shoulders, arms, chest, and back [1,8]

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Its five filmsreleased yearly between 2008 and 2012collectively grossed over $3.3 billion worldwide