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*Correspondence: Bonglee Kim, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Mechanisms Anti-oxidation The exact mechanisms of how hydrogen acts still remain a mystery in the scientific community

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These insights are reflected in recent TME physiologic MRI studies showing that approximately two-thirds of vital GBM tumor tissue is dominated by aerobic glycolysis, with a glycolysis-to-OxPhos ratio of 38% to 19%, while a significant 24% of the tumor also displays hypoxia (53)

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