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These factors make drug development a very challenging task
The E3 ubiquitin ligase Trim63 (also known as MuRF1) can regulate the activity of key enzymes involved in fatty acid oxidation (FAO), such as CPT1A and ACOX1, by affecting the activity of peroxisome proliferator-activated receptor (PPAR)
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doi: 10.1038/mt.2008.49 107 StudebakerAWHutzenBJPiersonCRHaworthKBCripeTPJacksonEMet al
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