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We found no indications of an altered placental mitochondrial content between any of the three PE subclasses and all control groups when using citrate synthase expression and mitochondrial complex IV (COX-IV) activity assays as surrogates of the mitochondrial content (40, 41) (Fig S1B and C)

It stimulates dermal fibroblast proliferation, regulates matrix metalloproteinases, and supports collagen turnover