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Description
Fraser et al
10.1038/nature08268 90 SchlaepferI
Amino acid sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 Molecular weight: ~1024.18 Da Molecular formula: C50H69N15O9 Number of amino acids: 7 (with N-terminal acetylation and C-terminal amidation) Cyclization: Lactam bridge between Asp (side chain carboxyl) and Lys (side chain amino) Ring size: 23-membered macrocyclic lactam Key modifications from alpha-MSH: Nle4 replaces Met4 (oxidation resistance), D-Phe7 replaces L-Phe7 (increased potency), truncation to 7 residues, cyclization via Asp-Lys lactam Contains D-Phe (non-natural stereochemistry at position 7) N-terminal: acetylated
I don't wear makeup on a daily basis anymore, so I love looking in the mirror and seeing how my new lips look against my luminous skin
Understanding these links helps us see why researchers study Melanotan peptides for broader medical applications
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