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Glossary SCD sickle cell disease OA osteoarthritis HH hereditary hemochromatosis HFE homeostatic iron regulator HAMP hepcidin antimicrobial peptide Tf transferrin TfR2 transferrin receptor-2 HJV hemojuvelin MMP13 matrix metalloproteinase-13 ADAMTS5 a disintegrin and metalloproteinase with thrombospondin motifs 5 KO knockout TNF- tumor necrosis factor- IL-1 interleukin-1 FAC ferric ammonium citrate ROS reactive oxygen species TfR transferrin receptor BMSCs bone marrow mesenchymal stem cells RANKL receptor activator of nuclear factor-kappa B ligand BMMs bone marrow-derived macrophages OPG osteoprotegerin DFO deferoxamine MAPK mitogen-activated protein kinase Runx2 runt-related transcription factor 2 DMT1 divalent metal transporter 1 PI3K phosphatidylinositol 3-kinase JAK janus kinase STAT3 signal transducer and activator of transcription 3 FLSs fibroblast-like synoviocytes RA rheumatoid arthritis ALP alkaline phosphatase OPN osteopontin

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Intramuscular injection may occasionally cause skin rash, itching, diarrhea, and allergic asthma

doi: 10.1016/s0046-8177(99)90009-6