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In the recent time, and by multivariable-adjusted analysis, factors such as female sex, diabetes, liver disease, proton pump inhibitors, abdominal pain, increased age, body mass index (BMI), and liver stiffness were associated with gallstone disease, while non-Hispanic Black and non-Hispanic Asian race and alcohol were inversely associated

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doi: 10.3390/ijerph18010001

Much of this research is conducted with animal models or has only been tested in a lab at this time

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In another in vivo study, the absence of 5 nAChR in hemiparkinsonian mice was associated with reduced dopaminergic neurodegeneration and motor dysfunction, suggesting that nAChRs containing the 5 subunit may represent novel therapeutic targets for PD