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Materials and methods Ethics approval In accordance with the WMA Declaration of Helsinki-Ethical Principles for Medical Research Involving Human Participants 2024 [37] and the Institutional Ethics Committee at the Rajendra Memorial Research Institute of Medical Sciences, under the Indian Council of Medical Research in Patna, Bihar, approved this study [IEC Letter No

Present and future therapies of hepatitis B: from discovery to cure

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At high concentrations, Zn 2+ triggers full activation of IIb3 integrins and promotes platelet aggregation via the protein kinase C (PKC)/myosin light chain (MLC) phosphorylation pathway, whereas at low concentrations, Zn 2+ inhibits platelet activation and thrombus formation by enhancing prostacyclin I (PGI) signaling through the cyclic adenosine monophosphate (cAMP)/vasodilator-stimulated phosphoprotein (VASP) pathway (138140)