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Unexpectedly, subjects receiving CNTF in clinical trials for this indication experienced weight losses of 10--15%, prompting researchers to consider using CNTF to treat obesity [71]
Histological analysis of mouse skin showed induction of anagen terminal hair follicles in P5-treated animals compared to vehicle controls [6]
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A systematic approach combining unbiased global metabo-lomics and gene microarray identified the folate-methionine cycle and its directly tethered de novo purine biosynthesis pathway as the cellular metabolic target of MOTS-c [4]
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