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You may have health issues that interfere with your bodys ability to absorb the nutrient, you might not be getting enough in your diet, or you could be taking drugs that lower the levels of B12 in your body

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Application of chitosan-based nanoparticles for the treatment of liver diseases, in Chitosan-based nanoparticles for biomedical applications (Elsevier), 275287
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Bone-targeting liposome formulation of Salvianic acid A accelerates the healing of delayed fracture Union in Mice