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doi: 10.1016/s0306-4522(99)00442-x

They discovered that the fatty acid metabolism-related gene signature plays a potential role in the mechanisms of ionizing radiation-induced fibrosis

PLoS ONE 8:e57251

As a central energy sensor, AMPK extends lifespan by promoting autophagy via mTOR inhibition and ULK1 activation, enhancing mitochondrial function through PGC-1/SIRT1 signaling and improving the NAD + /NADH balance, suppressing inflammatory responses via NF-B inhibition, and modulating stress resistance via the FOXO3/p53 pathways, thereby linking metabolic regulation to aging suppression 41

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