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The vast majority of compounds show a reduced or even complete loss of the therapeutic effect under hypoxic conditions
Autophagy is critical in degrading damaged cellular organelles and nutrient recycling
Additional investigations have examined its role in xenobiotic metabolism, heavy metal chelation, and immune cell function modulation
Inactivation of tumor suppressor genes, p53 and Rb1, in plasma cell dyscrasias
Hellevik T, Martinez-Zubiaurre I
