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A Herxheimer reaction (often called a Herx) occurs when bacteria are killed during treatment, triggering an inflammatory response that can temporarily worsen symptoms

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Distribution of glutathione transferases in Gram-positive bacteria and Archaea

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The absorbed Fe 2+ is oxidized to Fe 3+ in epithelial cells of small intestine, which is then bound to transferrin (TF) in plasma and transported to various sites of utilization or storage [24,25,26]