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NAD+ levels in human skin decline with age, and this decline affects multiple repair mechanisms simultaneously: DNA repair capacity (through PARP enzyme activity), mitochondrial energy production in skin cells, autophagy of damaged proteins, including glycated collagen, and the sirtuin-mediated preservation of collagen integrity

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Immunocytochemical analysis confirmed that these newly formed spines were functional, showing similar percent correlations with presynaptic markers VGLUT1 and synapsin, and postsynaptic marker, PSD-95, as control-treated neurons

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These can include mild irritation when applied topically