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glutathione ammonia Scheme showing the origin of ammonia/ammonium production and 16.9 The Nitrogen Metabolism Inhibitor
Description
Kliment, C
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10.1016/s0163-7827(03)00014-6 101 UrsiniF.MaiorinoM
The function of GSH in hepatocytes has been investigated by pharmacological inhibition or genetic ablation of the glutamate-cysteine ligase (GCL), the rate-limiting and regulatory enzyme in GSH biosynthesis
CBS is a cytosolic homotetrametic enzyme of about 63 kDa subunits that binds two cofactors, pyridoxal 5phosphate (PLP) and haem (Meier et al ., 2001)
On top of the role of NAD + as a direct substrate for the TCA and ETC, much of the influence of NAD + on mitochondrial homeostasis is through the NAD + -consuming enzymes sirtuins
