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The staining was performed using a BenchMark XT Immunostainer (Ventana Medical Systems, Inc., Tucson, AZ, USA), according to the manufacturer's instructions

This neuroinflammation facilitates further aggregation and propagation of -synuclein contributes to neurodegeneration and the progression of PD ( Bacteroides vulgatus , Parabacteroides distasonis , Lactobacillus sali var ius , and various Clostridium species, have been reported to alter the neuroinflammatory signaling that impacts the functioning of the brain ( , these cytokines further stimulate neutrophils and macrophages, resulting in the onset of intestinal inflammation (Figure 1)

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Marshall European Center for Security Studies (Marshall Center), established in 1993 and located in Garmisch-Partenkirchen, Germany
