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Knezevic et al., 2021b) and central vessels (Gojkovic et al., 2021a) or after the intragastric application of absolute alcohol (Gojkovic et al., 2021b) and intraperitoneal application of the lithium overdose (Strbe et al., 2021)
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What Makes Periorbital Skin So Vulnerable A 2019 clinical assessment published in Clinical, Cosmetic and Investigational Dermatology confirmed that under-eye dark circles correlate with measurably thinner skin, higher hemoglobin index (a marker of vascular prominence), and a higher melanin index all pointing to both vascular and pigmentary contributors rather than just one single cause
Chronic inflammation in diabetes causes anemia primarily through the action of inflammatory cytokines and disruptions in iron metabolism, resulting in anemia of chronic disease (ACD)
Most people start noticing improvements within a few weeks to a few months after beginning treatment

doi: 10.1016/j.jdermsci.2013.05.004
