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NAD + can be converted to NADP + through the action of cytoplasmic NAD + kinase (encoded by the NADK gene) or mitochondrial NAD + kinase (encoded by the NADK2 gene)

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In complementary studies, they further demonstrate that methanobactin therapy, a bacteria-derived chalkophore with high copper affinity, restores intestinal barrier integrity, improves mitochondrial ultrastructure, and reduces inflammatory changes in WD animal models and ATP7B-deficient human enterocytes [9]

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