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The search plan was made in Medline for Pubmed with the following mesh terms: IGF-1 and metabolism, carbohydrate, lipids, proteins, amino acids, metabolic syndrome, cardiovascular disease, diabetes between the years 19632015

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After the drug program ended, the compound was repositioned by its sponsor as a metabolic-health ingredient, supported by a self-affirmed generally recognized as safe (GRAS) characterization and safety/metabolism publications