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Oxidation of these enzymes has been reported to lead to a reduction of their activities 33,35,62 , enabling diversion of carbon flux from glycolysis towards nucleotide and glutathione synthesis 62 : Slowing glycolysis down enables for glycolytic intermediates to be pushed towards serine synthesis and consequently folate cycle and/or trans-sulfuration pathway 63 to provide glycine and cysteine, the building blocks for glutathione production (Figs

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With respect to iron metabolism, LPS suppresses hepatic Hepc expression through the TLR4/NF-B pathway while upregulating the iron exporter FPN1 in duodenal enterocytes, thereby enhancing intestinal iron absorption (58)

Neurosci Lett 1998;244:736

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