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doi: 10.1111/j.1468-3083.2009.03475.x

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Biochem Biophys Res Commun 513, 2227

Moreover, the presence of HSP60 on the cell surface and in the extracellular milieu has been linked with the activation of immune responses, where it acts as a damage-associated molecular pattern (DAMP) and signals to immune cells, thereby influencing inflammatory pathways, 134,135 which is particularly relevant in understanding autoimmune diseases and cancer

Recent advances in our understanding of the etiology of rosacea also include predisposing factors such as genetic susceptibility as well as its potential association with other chronic disorders [15,16]

Some phytochemicals also directly interact with electrophiles, but their action may also be realized through activation of GSH synthesis/resynthesis and reduction